Petasin

Petasin inhibits adipogenesis in cell 3T3-F442A with an IC50 of 0.95 μM. Petasin inhibits the expression of lipid synthesis factors ACC1, FAS and SCD1 by inhibiting transcription factors PPARγ and C/EBPα, as well as targeting TRPA1 and TRPV1 channels . Petasin inhibits mitochondrial complex I, thereby inhibiting tumor growth and metastasis. Petasin activates AMPK signaling pathway, participating in regulation of glucose and lipid metabolism. Petasin is orally active[1].

26577-85-5

12352211

AMPK; Mitochondrial Metabolism; PPAR; TRP Channel

Cell Cycle/DNA Damage; Epigenetics; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Cancer; Metabolic Disease

C[C@@]12C(CC[C@H]([C@@H]2C)OC(/C(C)=C\C)=O)=CC([C@@H](C1)C(C)=C)=O

C20H28O3

316.43

[1]Uesugi S, et al., Petasin is the main component responsible for the anti-adipogenic effect of Petasites japonicus. Fitoterapia. 2022 Mar;157:105130.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N10612/

Natural Products

No Development Reported