PF-04382923

PF-04382923 is a humanized IgG2Δa monoclonal antibody. PF-04382923 binds with high affinity to the free C-terminal regions of the amyloid-β peptides Aβ1-40 and Aβ1-42. PF-04382923 is indicated for the study of geographic atrophy (GA) associated with dry age-related macular degeneration (ARMD) [1].

12352211

Amyloid-β

Neuronal Signaling

Neuroscience-Neurodegeneration

Neurological Disease

[1]Liao K, et al. A Mechanism-Based Binding Model for the Pharmacokinetics and Pharmacodynamics (PK-PD) of RN6G (PF-04382923), a Humanized Monoclonal Antibody against Amyloid β Peptides, in Subjects with Dry, Age-Related Macular Degeneration Including Geographic Atrophy[J]. Investigative Ophthalmology & Visual Science, 2013, 54 (15) : 3287-3287.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P991534/

Reference compound1

No Development Reported