Gecertificeerd

PF-04840082

Name: PF-04840082
Brand: Genprice.nl
SKU: 26526973
Availability: InStock

Catalog #: HY-P991569

Maat: 1 Each

Kwaliteit

ISO Gecertificeerd

Levering

24-48 uur

Prijs -1%

BTW niet inbegrepen

Gratis verzending vanaf €100

Aantal:

Technische Specificaties

Description

PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. PF-04840082 binds the physiological antagonist (Dkk-1) of the Wnt/LRP5 signal pathway and increases bone mass and bone mass density by activating osteoblasts. PF-04840082 can be used for osteoporosis research[1][2].

UNSPSC

12352203

Target

Wnt

Related Pathways

Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease

References & Citations

[1]Betts AM, et al. The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. J Pharmacol Exp Ther. 2010 Apr;333 (1) :2-13. |[2]Kovács B, et al. The Wnt Signalling Pathways: A Short Review and Specific Roles in Bone Biochemistry[J]. Acta Medica Marisiensis, 2017, 63 (3) .

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P991569/

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Beschrijving

PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. PF-04840082 binds the physiological antagonist (Dkk-1) of the Wnt/LRP5 signal pat

Specificaties

ProductnaamPF-04840082

Categorie

Beschikbare grootte1 Each

CatalogusnummerHY-P991569

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