PF-06840003
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
PF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1) .1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3
Unconjugated
White solid
-20°C
Beschrijving
PF-06840003 Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
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