PF-4 (CXCL4)

PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

PF4; PF-4; CXCL4; SCYB4

5196

P02776

NP_002610.1

NM_002619.2

4q12-q21

Human

Mouse, Trout, Human, Bacteria

EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract human fibroblasts using a concentration range of 1.0-10.0 ng/ml.

70

Lyophilized

7.8 kDa

E. coli