PF-4136309
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
PF-4136309 (1341224-83-6) is a potent (hIC50 = 5.2 nM, mIC50 = 13 nM, rIC50 = 17 nM) and selective inhibitor of CCR2.1 PF-4136309 significantly decreased inflammatory monocytes in a mouse model of pancreatic cancer.2 In combination therapy with the FOLFIRINOX regimen, PF-4136309 reversed immune suppression in the tumor microenvironment causing an influx of tumor infiltrating lymphocytes leading to overall enhanced efficacy in a phase 1b study.3
Unconjugated
Off-white solid
-20°C
Beschrijving
PF-4136309 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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