PF-670462 sulfonzuur
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Potent inhibitor of casein kinase 1ε/δ (CK1ε, IC50 = 7.7 nM; CK1δ, IC50 = 14 nM) .1 It is a circadian clock modifier that caused robust phase delays in rats1 and Cynomolgus monkeys2. PF-670462 caused nuclear retention of the clock protein PER resulting in period lengthening in a phase-specific manner that was dependent on CK1δ inhibition and not CK1ε.3 It improved cognitive performance and reduced amyloid load in various mouse models of Alzheimer’s disease.4-6 PF-670462 slowed the progression of and increased survival of chronic lymphocytic leukemia in mice alone and in combination with Ibrutinib.7
Unconjugated
Off-white solid
-20°C
Beschrijving
PF-670462 sulfonzuur Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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