PFK15
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
PFK15 is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) . PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50 = 207 nM) without inhibiting 96 other kinases.1 PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth in vitro and in vivo. PFK15 has been shown to inhibit tumor growth in various cancer models.2,3
Unconjugated
Pale yellow solid
-20°C
Beschrijving
PFK15 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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