PGAM5 (CT) Antilichaam

PGAM5 Antibody: PGAM5 is a central mediator for programmed necrosis induced by TNF and may be a regulator of mitochondrial dynamics. It displays phosphatase activity for serine/threonine residues, dephosphorylates and activates MAP3K5 kinase. It has apparently no phosphoglycerate mutase activity and is a substrate for a KEAP1-dependent ubiquitin ligase complex. It is also contributes to the repression of NFE2L2-dependent gene expression

192111

Q96HS1

Q96HS1

Human, Mouse, Rat

9517

Unconjugated

Primary Antibodies

Signal Transduction

PGAM5 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1203 – A549 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: gorilla (100%) ; Chimpanzee (100%) ; monkey (100%) .

PGAM5 Antibody is supplied in PBS containing 0.02% sodium azide

None

Blue Ice

PGAM5 antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human PGAM5 has 2 isoforms, including isoform 1 (289aa, 32kD), and isoform 2 (255aa, 28kD) . Mouse PGAM5 has 2 isoforms, including isoform 1 (288aa, 32kD) and isoform 2 (287aa, 31.9kD) . Rat PGAM5 has one isoform (288aa, 32kD) . 9517 can detect PGAM5 in human, mouse and rat

PGAM5

Cat. No. 1282 – 3T3/NIH Cell Lysate

Cat. No. 1403 – Mouse Brain Lysate

PGAM family member 5, mitochondrial serine/threonine protein phosphatase

Homo sapiens

Lo S. et al. Exp. Cell Res. 2018; 314 (8) : 1789-1803

Takeda et al. PNAS 2009; 106 (30) : 12301-12305

Want et al. Cell 2012; 148 (1-2) ; 228-243

Serine/threonine-protein phosphatase PGAM5 mitochondrial, Bcl-XL-binding protein v68, Phosphoglycerate mutase family member 5

ELISA, WB, IF

150417955

Liquid