PGP9.5 Antilichaam / UchL1

This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1) . Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.

Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL

P09936

Human

A recombinant human UCHL1 protein was used as the immunogen for the PGP9.5 antibody.

UCHL1/8153

IHC-P, WB

Protein G affinity

Purified

This PGP9.5 antibody is available for research use only.

Aliquot the PGP9.5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the PGP9.5 antibody should be determined by the researcher.

Cytoplasm, Endoplasmic reticulum membrane

Western blot testing of human brain tissue lysate with PGP9.5 antibody (clone UCHL1/8153) . Predicted molecular weight ~25 kDa.