Ph73 (Ab 99) Antilichaam

This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined.

7161

O15350

NP_001119712.1

Human, Mouse, Rat

P73 (Ab-99) antibody was raised against a peptide sequence around aa.97~101 (S-P-Y-A-Q) derived from Human P73.

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

80 kDa

This antibody detects endogenous level of total p73 protein.

Western Blot: 1:500~1:1000

TP73

Tumor protein p73

Homo sapiens

Yuan ZM, et al. (1999) Nature. 399 (6738) : 814-817.

P73, TP73, TRP73, p53-related protein, p73-alpha

WB

187828902

Liquid