PHAP Antilichaam

PHAP Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

8125

P39687

P39687

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

PHAP Antibody is DEAE purified.

Cat. No. 1207 - Raji Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (85%)

PHAP Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PHAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

35 kDa

IgG

ANP32A

Cat. No. 1308 - Human Small Intestine Tissue Lysate

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

Homo sapiens

Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC , Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science. 2003;299 (5604) :223-6.

Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science. 2003 10;299 (5604) :214-5.

PHAP Antibody: LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32

ELISA, WB, IHC-P, IF

730318

Liquid