PHAP I Antilichaam

PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

8125

P39687

P39687

Human, Mouse, Rat

3151

Unconjugated

Primary Antibodies

Apoptosis

PHAP I Antibody is DEAE purified.

Cat. No. 1207 - Raji Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (85%)

PHAP I Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PHAP I antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.

ANP32A

Cat. No. 1416 - Mouse Testis Tissue Lysate

Cat. No. 1476 - Rat Testis Tissue Lysate

Cat. No. 1408 - Mouse Small Intestine Tissue Lysate

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

Homo sapiens

Jiang et al. Science. 2003;299 (5604) :223-6.

Nicholson and Thornberry. Science. 2003 10;299 (5604) :214-5.

16489023

23652204

Parrish. Regulation of Apoptosis Following Mitochondrial Cytochrome c Release. Department of Pharmacology and Molecular Cancer Biology, Duke University. PhD Thesis, 2010.

PHAP I Antibody: LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32

ELISA, WB, IHC-P, IF

730318

Liquid