PHAP III Antilichaam

PHAP III Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

81611

Q9BTT0

NP_112182

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

PHAP III Antibody is affinity chromatography purified via peptide column.

Cat. No. 1203 - A549 Cell Lysate

1 mg/mL

PHAP III Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PHAP III antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures..

35 kDa

IgG

PHAP III has no cross-reaction to PHAP I and PHAP I2a.

ANP32E

Cat. No. 1211 - HepG2 Cell Lysate

Cat. No. 1308 - Human Small Intestine Tissue Lysate

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

Homo sapiens

Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC , Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science. 2003;299 (5604) :223-6.

Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science. 2003 10;299 (5604) :214-5.

PHAP III Antibody: LANPL, LANP-L, Acidic leucine-rich nuclear phosphoprotein 32 family member E, LANP-like protein

ELISA, WB, IHC-P, IF

13569879

Liquid