PHB-antilichaam - C-terminaal gebied : HRP (ARP32807_P050-HRP)

Prohibitin

PHB1, HEL-215, HEL-S-54e

5245

P35232

NP_002625

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human PHB

Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.

FUS; HUWE1; SUMO2; SPRTN; STAU1; MDM2; SUZ12; EED; RNF2; PARP1; NAP1L1; COX6C; LONRF3; FBXO6; ADRB2; HDAC5; RAF1; KRAS; RAPH1; IPO11; SMG5; YWHAZ; YWHAB; VDAC2; RPS4X; RPL7; PRKCD; PLEC; NPM1; LMNA; IGHG1; HSP90AB1; GTF3C1; DBN1; COL9A2; CAPZA1; SLC25A5

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB, IHC

Affinity Purified

PHB is supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

30kDa

Fraering, P.C., et al., (2004) Biochemistry 43 (30), 9774-9789

Wet Ice

272

PHB

PHB

Rabbit

Prohibitin

NM_002634

AEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLS