PHF14 Antilichaam

PHF14, a novel plant homology domain (PHD) transcription factor, controls the proliferation of mesenchymal cells by regulating PDGFR alpha expression in embryonic development (1) . PHD finger transcription factors are concerned with transcriptional regulation by interacting with modified histones (2), and dysregulation of several genes encoding PHD finger transcription factors, such as ING1 and RBP2, has been found in human cancer diseases suggesting these factors have an important role for cancer cell proliferation. PHF14 is a potential target for new treatments of lung fibrosis (1, 3) .

9678

O94880

NP_055475

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

PHF14 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

PHF14 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PHF14 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

PHF14 antibody is human, mouse and rat reactive. Multiple isoforms of PHF14 are known to exist.

PHF14

Cat. No. 17-010 - HEK293 Cell Slide

PHD finger protein 14

Homo sapiens

Kitagawa M, Takebe A, Ono Y, et al. Phf14, a novel regulator of mesenchyme growth via platelet-derived growth factor (PDGF) receptor-a. J. Biol. Chem. 2012; 287:27983-96.

Musco G and Peterson P. PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus. Epigenetics 2008; 3:310-4.

Musselman CA and Kutateladze TG. PHD fingers: epigenetic effectors and potential drug targets. Mol. Interv. 2009; 9:314-23.

PHF14 Antibody : KIAA0783, PHD finger protein 14

ELISA, WB, IF

55769548

Liquid