PHKA1 Antilichaam

Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.

5255

P46020

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 600-820 of human PHKA1 (NP_001116142.1) .

Unconjugated

Primary Antibodies

Cancer, Neuroscience, Signal Transduction

Affinity purification

U-87MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 137kDa

IgG

WB: 1:500 - 1:2000

PHKA1

Jurkat

HeLa

Mouse heart

Phosphorylase kinase regulatory subunit alpha 1

Homo sapiens

PHKA, phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform, phosphorylase kinase alpha M subunit, phosphorylase kinase, alpha 1 (muscle), muscle glycogenosis

WB

Liquid