Phorbol 12,13-dibutyraat (GMP)

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a PKC activator and a potent skin tumor promoter[1][2].

37558-16-0

Phorbol dibutyrate (GMP) ; PDBu (GMP)

12352211

PKC

Epigenetics; TGF-beta/Smad

Cancer

O=C1C(C)=C[C@@]2([H])[C@]3(O)[C@@]([C@@](C4(C)C)([H])[C@@]4(OC(CCC)=O)[C@H](OC(CCC)=O)[C@H]3C)([H])C=C(CO)C[C@]12O

C28H40O8

504.61

[1]Singh J, et al. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301 (2) :G317-25.|[2]Szallasi Z, et al. Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes. J Biol Chem. 1994 Nov 4;269 (44) :27159-62.|[3]Middleton JP, et al. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25;268 (21) :15958-64.

Blue Ice

Keep sealed and protect from light, store at 2-8°C

http://file.medchemexpress.com/batch_PDF/HY-18985G/

GMP Small Molecules

No Development Reported