Phoron

Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (Km = 0.9 mM) . Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.

504-20-1

Diisopropylidene acetone

12352211

H302, H315, H319, H335

Glutathione S-transferase

Metabolic Enzyme/Protease

Cancer; Metabolic Disease

99.89

O=C(/C=C(C)/C)/C=C(C)\C

C9H14O

138.21

H302, H315, H319, H335

[1]van Doorn R, et al. Synergistic effects of phorone on the hepatotoxicity of bromobenzene and paracetamol in mice. Toxicology. 1978 Nov;11 (3) :225-33. |[2]Sunahara GI, Chiesa A. Phorone (diisopropylidene acetone), a glutathione depletor, decreases rat glucocorticoid receptor binding in vivo. Carcinogenesis. 1992 Jul;13 (7) :1083-9.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W017785/Phorone-SDS-MedChemExpress.pdf

Natural Products

No Development Reported