Phoyunbene B

Phoyunbene B is a similar substance to Resveratrol. Phoyunbene B exhibits stronger growth inhibitory activity against human liver cancer cells HepG2 compared to Resveratrol. Phoyunbene B induces G2/M phase cell cycle arrest and apoptosis. Phoyunbene B increases Bax/Bcl-2 and activates Caspase-3. Phoyunbene B inhibits the invasion and migration of cancer cells. Phoyunbene B can be used for research on liver cancer[1].

886747-62-2

12352005

H302-H312-H332

Apoptosis; Bcl-2 Family; Caspase; Drug Derivative

Apoptosis; Others

Cancer

COC1=CC(O)=CC(/C=C/C2=C(C(OC)=C(C=C2)O)OC)=C1

C17H18O5

302.32

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

[1]Wang G, et al. A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Bioorg Med Chem Lett. 2012 Mar 1;22 (5) :2114-8.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N9778/

Natural Products

No Development Reported