PIAS1 Antilichaam

PIAS1 Antibody: The PIAS proteins (protein inhibitor of activated STAT) play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS1. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS1 binds specifically to STAT1, inhibiting STAT1-mediated gene activation and also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS1 is a potent co-activator for CP2c-mediated alpha-globin expression in erythroid cells.

8554

O75925

NP_057250

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

PIAS1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1305 - Human Kidney Tissue Lysate

1 mg/mL

PIAS1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PIAS1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PIAS1

Protein inhibitor of activated STAT, 1

Homo sapiens

Liu B, Liao J, Rao X, et al. Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. USA1998; 95: 10626-31.

Shuai K and Liu B. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol.2005; 5:593-605.

Kang HC, Chae JH, Jeon J, et al. PIAS1 regulates CP2c localization and active promoter complex formation in erythroid cell-specific {alpha}-globin expression. Nuc. Acids Res.2010 Apr 26.

PIAS1 Antibody: GBP, ZMIZ3, DDXBP1, GU/RH-II, E3 SUMO-protein ligase PIAS1, Gu-binding protein, GBP

ELISA, WB, IHC-P, IF

7706637

Liquid