PIAS3 Antilichaam

PIAS3 Antibody: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.

10401

Q9Y6X2

NP_006090

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

PIAS3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

PIAS3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PIAS3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PIAS3

Protein inhibitor of activated STAT, 3

Homo sapiens

Shuai K and Liu B. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol.2005; 5:593-605.

Chung CD, Liao J, Liu B, et al. Specific inhibition of Stat3 signal transduction by PIAS3. Science1997; 278:1803-5.

Wang L and Banerjee S. Differential PIAS3 expression in human malignancy. Oncol. Rep.2004; 11:1319-24.

Zhang Q, Raghunath PN, Xue L, et al. Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J. Immunol.2002; 168:466-7

PIAS3 Antibody: ZMIZ5, E3 SUMO-protein ligase PIAS3, Protein inhibitor of activated STAT protein 3

ELISA, WB, IHC-P

115298686

Liquid