PIBF1 Antilichaam

PIBF1 Antibody: PIBF1 is synthesized during pregnancy in response to progesterone by T lymphocytes. PIBF1 inhibits arachidonic acid release, controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. It contains a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an ER membrane retention signal and N-glycosylation and phosphorylation sites. PIBF1 is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF1 is associated with the nucleus and functions as a transcription factor, whereas secretion of shorter forms which may act as cytokines is induced by activation of the cell.

10464

Q8WXW3

NP_006337

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

PIBF1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1309 - Human Placenta Tissue Lysate

1 mg/mL

PIBF1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PIBF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

83 kDa

IgG

Multiple isoforms of PIBF1 exists as a result of alternative splicing event.

PIBF1

Cat. No. 10-901 - Human Spleen Tissue Slide

Progesterone immunomodulatory binding factor 1

Homo sapiens

Laskarin G, Tokmadzic VS, Strbo N, et al. Progesterone induced blocking factor (PIBF) mediates progesterone induced suppression of decidual lymphocyte cytotoxicity. Am. J. Reprod. Immunol. 2002; 48:201-9.

Lachmann M, Gelbmann D, Kalman E, et al. PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome. Int. J. Cancer. 2004; 112:51-60

Polgar B, Kispal G, Lachmann M, et al. Molecular cloning and immunologic characterization of a novel cDNA coding for progesterone-induced blocking factor. J. Immunol. 2003; 171:5956-63.

Raghupathy R, Al-Mutawa E, Al-Azemi M, et al. Progesterone-induced blocking factor (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery. J. Reprod. Immunol. 2009; 80:91-9.

PIBF1 Antibody: PIBF, CEP90, C13orf24, PIBF, Progesterone-induced-blocking factor 1

ELISA, WB, IHC-P, IF

5576958

Liquid