PIC1 PA

1356469-36-7

Complement System

Immunology/Inflammation

PIC1 PA, a peptide consisting of 15 amino acids, serves as an effective analog of PIC1 that inhibits complement activation mediated by the classical pathway. Functionally, PIC1 PA interferes with the interaction between the C1s-C1r-C1r-C1s/MASPs and the collagen-like region (CLR) of C1q/MBL. It specifically binds to the CLR of C1q, with an average equilibrium dissociation constant (KD) of 33.3 nM when binding purified C1q.

C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(C)C)=O)CCC(O)=O)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)C)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)CCC(N)=O)=O)CS)=O)CS)=O)[C@H](CC)C)=O)CCC1

C71H123N19O21S2

1642.98

Ice Packs

-20°C