PIC1 PA (TFA)

PIC1 PA TFA is the trifluoroacetate salt form of PIC1 PA. PIC1 PA TFA is a 15-amino acid peptide that is a potent PIC1 analog that inhibits classical complement activation[1].

12352209

Complement System

Immunology/Inflammation

COVID-19-immunoregulation

Inflammation/Immunology

99.04

O=C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N1[C@@H](CCC1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N.O=C(O)C(F)(F)F.[x]

C71H123N19O21S2.xC2HF3O2

1642.98 (free base)

[1]Sharp JA, et al. Peptide inhibitor of complement c1, a novel suppressor of classical pathway activation: mechanistic studies and clinical potential. Front Immunol. 2014 Aug 22;5:406.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10827A/PIC1-PA-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported