PICALM Antilichaam

PICALM Antibody: PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP) .

8301

Q13492

NP_009097

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

PICALM Antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

PICALM Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PICALM antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PICALM

Cat. No. 10-301 - Human Brain Tissue Slide

Phosphatidylinositol binding clathrin assembly protein

Homo sapiens

Tebar F, Bohlander SK, and Sorkin A. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin mediated traffic. Mol. Biol. Cell1999; 10:2687-702.

Caudell D and Aplan PD. The role of CALM-AF10 gene fusion in acute leukemia. Leukemia2008; 22:678-85.

Harel A, Wu F, Mattson MP, et al. Evidence for CALM in directing VAMP2 trafficking. Traffic2008; 9:417-29.

Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet.2009; 41:1088-93.

PICALM Antibody: LAP, CALM, CLTH, Phosphatidylinositol-binding clathrin assembly protein, Clathrin assembly lymphoid myeloid leukemia protein

ELISA, WB, IF

56788366

Liquid