PIERCE1 Antilichaam

PIERCE1 Antibody: PIERCE1, also known as C9orf116, is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.

138162

Q5BN46

Q5BN46

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis

PIERCE1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

PIERCE1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PIERCE1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PIERCE1 antibody is predicted to not cross-react with other UPF0691 family members.

C9orf116

Cat. No. 17-208 - A-20 Cell Slide

Chromosome 9 open reading frame 116

Homo sapiens

Sung YH, Kim HJ, Devkota S, et al. Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response. Cancer Res. 2010; 70:10454-63.

Zhou BB and Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature 2000; 408:433-9.

Sung YH, Kim HJ, Lee HW, et al. Identification of a novel Rb-regulated gene associated with the cell cycle. Mol. Cells 2007; 24:409-15.

Kakiuchi S, Daigo Y, Tsunoda T, et al. 2003. Genome-wide analysis of organ-preferential metastasis of human small cell lung cancer in mice. Mol. Cancer Res. 1:485-99.

PIERCE1 Antibody: PIERCE1, RbEST47, UPF0691 protein C9orf116, p53-induced expression in RB-null cells protein 1, Pierce1

ELISA, WB, ICC

115430217

Liquid