PIEZO2 Antilichaam / FAM38B

PIEZO2 (Piezo-type mechanosensitive ion channel component 2), also called Protein FAM38B, is a transmembrane protein that spans the cell membrane and acts as a sensor for mechanical stimuli. When external forces, such as touch or pressure, are applied to the cell membrane, PIEZO2 responds by opening up and allowing ions to flow into the cell. This influx of ions triggers a signal that is transmitted to the brain, allowing us to perceive and respond to the touch sensation. It also plays a critical role in a variety of other sensory functions, including proprioception (the ability to sense the position of our body in space) and hearing. Recent studies have uncovered even more functions of PIEZO2 beyond sensory perception. It has been found to be involved in regulating lung development, bone formation, and even cell migration.

Western blot: 1:500-1:1000

Q9H5I5

Human

A portion of amino acids 2575-2604 from the human protein was used as the immunogen for the PIEZO2 antibody.

WB

Antigen affinity

Purified

This PIEZO2 antibody is available for research use only.

Aliquot the PIEZO2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

The stated application concentrations are suggested starting points. Titration of the PIEZO2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Western blot testing of human 1) HeLa, 2) HepG2 and 3) A549 cell lysate with PIEZO2 antibody. Expected molecular weight ~318 kDa.