PIG-Y Antilichaam

PIG-Y Antibody: Glycosylphosphatidylinositol (GPI) lipid anchoring is an important post-translational modification of proteins that takes place in the endoplasmic reticulum. The synthesis of GPI is initiated by GPI-N-acetylglucosaminyltransferase (GPI-GnT), a complex of proteins including PIG-A, PIG-H, PIG-C, GPI1, and DPM2. PIG-Y, the mammalian homolog to yeast Eri1p, is also thought to be involved in the biosynthesis of GPI. The PIG-Y gene encodes two proteins, one of which arises from leaky scanning of the mRNA.

84992

Q3MUY2

NP_116295

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

PIG-Y Antibody is affinity chromatography purified via peptide column.

Cat. No. 1304 – Human Liver Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rat: (94%)

PIG-Y Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PIG-Y antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This antibody only detects isoform 1 of PIG-Y.

PIGY

Cat. No. 10-901 - Human Spleen Tissue Slide

Phosphatidylinositol glycan anchor biosynthesis, class Y

Homo sapiens

Eisenhaber B, Maurer-Stroh S, Novatchkova M, et al. Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins. Bioessays2003; 25:367-85.

Watanabe R, Murakami Y, Marmor MD, et al. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. EMBO J.2000; 19:4402-11.

Murakami Y, Siripanyaphinoyo U, Hong Y, et al. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Mol. Biol. Cell2005; 16:5236-46.

PIG-Y Antibody: PIG-Y, Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y, Phosphatidylinositol-glycan biosynthesis class Y protein, PIG-Y

ELISA, WB, IHC-P, IF

14249680

Liquid