PIGA Antilichaam - middengebied: Biotine (ARP45344 P050-Biotine)

Phosphatidylinositol glycan anchor biosynthesis, class A

GPI3, PNH1, PIG-A, MCAHS2

5277

B3KUV7

NP_065206

Human, Mouse, Rat, Cow, Dog, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human PIGA

PIGA is a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene.This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized.

UBC; ELAVL1; PIGY; DPM2; PIGQ; PIGH; PIGP

Biotin

Polyclonal Antibody

WB

Affinity Purified

PIGA is supported by BioGPS gene expression data to be expressed in HEK293T

0.5 mg/ml

Cow: 86%; Dog: 93%; Human: 100%; Mouse: 93%; Pig: 79%; Rabbit: 79%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

19kDa

Traulsen, A., (2007) Stem Cells 25 (12), 3081-3084

Wet Ice

169

PIGA

PIGA

Rabbit

Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Ensembl ENSP00000416102

NM_020473

SVKSLCEGLEKAIFQLKSGTLPAPENIHNIVKTFYTWRNVAERTEKVYDR

A