PIK3C2B Mouse Monoclonal Antibody [Kloon ID: LBI2G3]

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) PIK3C2B mouse monoclonal antibody, clone LBI2G3

C2-PI3K

Homo sapiens phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta (PIK3C2B), transcript variant 2, mRNA.

5287

O00750

Unconjugated

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system

WB 1:2000~4000, IHC 1:150, IF 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

PIK3C2B

https://www.ncbi.nlm.nih.gov/gene/?term=5287

https://www.uniprot.org/uniprot/O00750