PIK3C3 Antilichaam

PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase class III), is a member of the PI3/PI4-kinase family (1) . It is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate and ubiquitously expressed with a highest expression in skeletal muscle (1,2) . PIK3C3 is involved in the endosome to lysosome transport and plays important roles in intracellular membrane trafficking and autophagy (3-5) .

5289

Q8NEB9

NP_002638

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy

PIK3C3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1408 - Mouse Small Intestine Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%)

PIK3C3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PIK3C3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

PIK3C3 antibody is human, mouse and rat reactive.

PIK3C3

Phosphatidylinositol 3-kinase, catalytic subunit type 3

Homo sapiens

Stopkova P, Saito T, Papolos DF, et al. Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia. Biol. Psychiatry 2004; 55:981-8.

Hal BS, Gabernet-Castello C, Voak A, et al. TbVps34, the trypanosome orthologue of Vps34, is required for Golgi complex segregation. J. Biol. Chem. 2006; 281:27600-12.

Backer JM. The regulation and function of class III PI3Ks: novel roles for Vps34. Biochem. J. 2008; 410:1-17.

Jaber N, Dou Z, Lin RZ, et al. Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart. Autophagy 2012; 8:707-8.

PIK3C3 Antibody: VPS34, hVps34, VPS34, Phosphatidylinositol 3-kinase catalytic subunit type 3, Phosphatidylinositol 3-kinase p100 subunit, PI3-kinase type 3

ELISA, WB

34761064

Liquid