PIK3R4 Antilichaam

PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4, also known as VPS15) is a 150kD adaptor protein that enhances the lipid kinase activity of PIK3 complexes and may be involved in regulating membrane trafficking late in the endocytic pathway and autophagy (1,2) . PIK3R4 is ubiquitously expressed and contains 7 WD repeats, 3 HEAT repeats and 1 protein kinase domain (1) . PIK3R4 is crucial for VPS34 function and is necessary for autophagosome formation in multicellular animals and reveal an important role of VPS15 in cellular protection against ubiquitin-positive protein aggregates (3-5) .

30849

Q99570

NP_055417

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy

PIK3R4 antibody is affinity chromatography purified via peptide column.

Cat. No. 1315 - Human Tonsil Tissue Lysate

1 mg/mL

PIK3R4 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PIK3R4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

PIK3R4 antibody is human, mouse and rat reactive.

PIK3R4

Phosphoinositide 3-kinase regulatory subunit 4

Homo sapiens

Herman PK, Stack JH, and Emr SD. A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery. EMBO J. 1991; 10:4049-60.

Stasyk OV, van der Klei IJ, Bellu AR, et al. A Pichia pastoris VPS15 homologue is required in selective peroxisome autophagy. Curr. Genet. 1999; 36:262-9.

Kihara A, Noda T, Ishihara N, et al. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 2001; 152:519-30.

Stack JH, DeWald DB, Takegawa K, et al. Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J. Cell Biol. 1995; 129:321-34.

Phosphoinositide-3-kinase regulatory subunit 4, p150, Phosphoinositide 3-kinase adaptor protein, PI3-kinase p150 subunit, PI3-kinase regulatory subunit 4, VPS15

ELISA, WB, IHC-P, IF

23943912

Liquid