PIM447 (LGH447) Hydrochloride
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
1210416-52-6
C13103-2mg
Pim
JAK/STAT
CC1CC (CC (C1) N) C2=C (C=NC=C2) NC (=O) C3=NC (=C (C=C3) F) C4=C (C=CC=C4F) F
C24H23F3N4O.HCl
PIM447 (LGH447) Hydrochloride is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs) . PIM447 induces apoptosis.
2 years -80 in solvent
Beschrijving
PIM447 (LGH447) Hydrochloride Beschikbaar in 2 mg. Wordt geleverd met droogijs. Bestel eenvoudig online met snelle levering.
Specificaties
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