Pin1 (fosfo Ser16) Antilichaam

Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.

5300

Q13526

NP_006212.1

Human, Mouse, Rat

Pin1 (phospho Ser16) antibody was raised against a peptide sequence around phosphorylation site of serine16 (R-M-S (p) -R-S) derived from Human Pin1 .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

18 kDa

IgG

The antibody detects endogenous level of Pin1 only when phosphorylated at serine 16.

Western Blot: 1:500~1:1000

PIN1

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Homo sapiens

Lee YC, et al. (2013) J Cell Sci 126, 4862-72. Ando K, et al. (2013) Neurobiol Aging 34, 757-69. Nechama M, Lin CL, Richter JD (2013) Mol Cell Biol 33, 48-58.

PPIase Pin1, Rotamase Pin1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, EC 5.2.1.8

WB

5453898

Liquid