PINK1 Antilichaam

The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1) . PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2) . PINK1 is cleaved by the mitochondrial protease PARL (3) . Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4) .

65018

Q9BXM7

NP_115785

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy, Neuroscience

PINK1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1202 - A431 Cell Lysate

1 mg/mL

PINK1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PINK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

PINK1 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will only detect the longer isoform. PINK1 antibody will detect the cleaved and uncleaved form of PINK1.

PINK1

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Cat. No. 1466 - Rat Spleen Tissue Lysate

PTEN induced putative kinase 1

Homo sapiens

Matsuda S, Kitagishi Y, and Kobayashi M. Function and characteristics of PINK1 in mitochondria. Oxid. Med. Cell. Longev. 2013;601587.

Corti O, Lesage S, and Brice A. What genetics tells us about the causes and mechanism of Parkinson's disease. Physiol. Rev. 2011; 91:1161-218.

Deas E, Plun-Favreau H, and Gandhi S, et al. PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum. Mol. Genet. 2011; 20:867-79.

Valente EM, Abou-Sleiman PM, Caputo V, et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004; 304:1158-60.

PINK1 Antibody: BRPK, PARK6BRPK

ELISA, WB, IHC-P, IF

14165272

Liquid