Piperacilline (hydraat)

Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam[2][3].

66258-76-2

Pipracil (hydrate)

12352005

H317-H412

Antibiotic; Bacterial; Beta-lactamase; Penicillin-binding protein (PBP)

Anti-infection

Cancer; Infection

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](NC(N3C(C(N(CC)CC3)=O)=O)=O)C4=CC=CC=C4)=O)N1C2=O)O.O

C23H29N5O8S

535.57

P261-P272-P273-P280-P302+P352-P362+P364-P501

[1]Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978, 13 (3) :358-67. |[2]Bodey GP, et al. Piperacillin: In Vitro Evaluation. Antimicrob Agents Chemother. 1978, 14 (1) :78-87. |[3]Harada Y, et al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014, 20 (11) :O831-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1923A/

Reference compound1

Phase 4