PIWI-L1 Antilichaam

PIWI-L1 Antibody: PIWI-L1 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L1 is thought to play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells as removing PIWI-L1 protein from single germline stem cells significantly decreases the rate of their division. Recent studies have shown that overexpression of PIWI-L1 (as well as other PIWI-like proteins) are potential biomarkers for colon and other cancers.

9271

Q96J94

AAK69348

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

PIWI-L1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (94%)

PIWI-L1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PIWI-L1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PIWIL1

Cat. No. 1211 - HepG2 Cell Lysate

Piwi-like 1 (Drosophila)

Homo sapiens

Thomson T and Lin H. The biogenesis and function PIWI proteins and piRNAs: progress and prospect. Annu. Rev. Cell Dev. Biol.2009; 25:355-76.

Cox DN, Chao A, and Lin H. PIWI encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells. Development2000; 503-14.

Li L, Yu C, Gao H, et al. Argonaute proteins: potential biomarkers for human colon cancer. BMC Cancer2010; 10:38.

PIWI-L1 Antibody: HIWI, MIWI, PIWI, CT80.1, HIWI, Piwi-like protein 1

ELISA, WB, IHC-P, IF

14579645

Liquid