PK11007
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
PK11007 reactivates mutant p53 via selective alkylation of two cysteine residues without compromising DNA-binding ability.1 p53 target genes p21 and PUMA were activated by treatment with PK11007. Mutant p53-containing cancer cells were more sensitive to PK11007 than wild-type with mutant cells showing greatly reduced viability. It also generated high levels of reactive oxygen species and induced ER stress in a p53-independent (and dependent on glutathione depletion) manner that resulted in cell death. PK11007 inhibited cellular proliferation, induced apoptosis, and blocked cell migration in a panel of 17 breast cancer lines including triple-negative breast cancer (IC50s: 2.3 to 42.2 µM) .2
Unconjugated
White solid
-20°C
Beschrijving
PK11007 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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