PKC-nr. (PRKD3) (NM 005813) Menselijk aanbevolen eiwit

This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

Purified recombinant protein of Human protein kinase D3 (PRKD3), Met300-Pro508, with N-terminal His tag, expressed in E. coli, 50ug

EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN

23683

O94806

NM_005813

2p22.2

E. coli

N-His

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Druggable Genome, Protein Kinase

23.8 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

PRKD3

Human

NP_005804

https://www.ncbi.nlm.nih.gov/gene/23683

https://www.uniprot.org/uniprot/O94806

https://www.ncbi.nlm.nih.gov/nuccore/NM_005813

https://www.ncbi.nlm.nih.gov/nuccore/NP_005804