PKCB (fosfo Ser661) Antilichaam

Calcium-activated, phospholipid- and diacylglycerol (DAG) -dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1.

5579

P05771

NP_002729.2

Human, Mouse, Rat

PKCB (phospho Ser661) antibody was raised against a peptide sequence around phosphorylation site of serine 661 (G-F-S (p) -Y-T) derived from Human PKCB.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

77 kDa

IgG

The antibody detects endogenous level of PKCB only when phosphorylated at serine 661.

Western Blot: 1:500~1:1000

PRKCB

Protein kinase C, beta

Homo sapiens

Zhu M, Chen J, Jiang H, Miao C (2013) Cardiovasc Diabetol 12, 13

Leonard TA, et al. (2011) Cell 144, 55-66

Qiao M, et al. (2010) Mol Cell 38, 512-23

PIM-1, EC 2.7.11.1

WB

20127450

Liquid