PKCtheta (Ab 695) Antilichaam

This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR) -mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-κ -B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

5588

Q04759

NP_006248.1

Human, Mouse, Rat

PKCtheta (Ab-695) antibody was raised against a peptide sequence around aa.693~697 (N-F-S-F-M) derived from Human PKCΘ .

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

80 kDa

This antibody detects endogenous level of total PKCΘ protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

PRKCQ

Protein kinase C, theta

Homo sapiens

Xu ZB, et al. (2004) J Biol Chem 279:50401-50409Thebault S, et al. (2004) Mol Immunol 40: 931-942

PRKCT, nPKC-theta, MAPTL, MTBT1, TAU, KPCT, PKC-theta, PKCQ, PRKCQ, PRKCT

WB, IHC

5453976

Liquid