PKM1 / 2 Antilichaam

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

5315

P14618

NP_872270.1

Human

PKM1/2 antibody was raised against a peptide sequence around aa. 36~40 (D-S-P-P-I) derived from Human PKM1/2.

Unconjugated

Primary Antibodies

Stem Cell

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

60 kDa

This antibody detects endogenous levels of total PKM1/2 protein.

Western Blot: 1:1000

PKM

Pyruvate kinase, muscle

Homo sapiens

Christofk, H. R. et al. (2008) Nature 452, 230-3. Mazurek, S. et al. (2005) Semin Cancer Biol 15, 300-8. Dombrauckas, J. D. et al. (2005) Biochemistry 44, 9417-29. Hitosugi, T. et al. (2009) Sci Signal 2, ra73.

PK3, TCB, OIP3, PKM2, CTHBP, THBP1, HEL-S-30, C10orf66, HOYS6, PKM, PK3, PK2

WB

33286420

Liquid