PKM2 Antilichaam - middengebied: Biotine (ARP57789_P050-Biotine)

Pyruvate kinase, muscle

PK3, TCB, p58, OIP3, PKM2, CTHBP, THBP1, HEL-S-30

5315

P11980

NP_002645

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human PKM2

This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

LNX1; NXT2; HUWE1; ISG15; UBC; POLE2; FUS; SUMO2; SUMO3; STAU1; MDM2; SUZ12; EZH2; IPO11; TWF2; PDLIM5; NPLOC4; PLIN3; UBA2; EIF4A3; ANP32A; SRP14; RAD23B; PPP1CA; PIN1; CTPS1; CBS; CAPZA2; ACAT2; NLK; FBXO6; YWHAQ; RAF1; IGSF8; HDAC6; MAPK7; NPM1; CDK2

Biotin

Polyclonal Antibody

WB

Affinity Purified

PKM is supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Sheep: 77%; Yeast: 85%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

58kDa

Wet Ice

531

PKM

PKM

Rabbit

Pyruvate kinase isozymes M1/M2

NM_002654

HLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQ