PKN1 Antilichaam

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

5585

Q16512

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PKN1 (NP_002732.3) .

Unconjugated

Primary Antibodies

Signal Transduction

Affinity purification

U-251MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 120kDa

IgG

PKN1

A-549

293T

HeLa

HepG2

HT-1080

Protein kinase N1

Homo sapiens

DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1, serine/threonine-protein kinase N1, protease-activated kinase 1, protein kinase C-like 1, protein kinase C-like PKN, protein kinase C-related kinase 1, protein kinase PKN-alpha, serine-threonine kinase N, serine/threonine protein kinase N

WB, IHC

Liquid