PKR (Ab 451) Antilichaam

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

5610

P19525

NP_001129123.1

Human

PKR (Ab-451) antibody was raised against a peptide sequence around aa.449~453 (K-G-T-L-R) derived from Human PKR.

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

68 kDa

This antibody detects endogenous level of total PKR protein.

Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

EIF2AK2

Eukaryotic translation initiation factor 2-alpha kinase 2

Homo sapiens

Ingrid K. Ruf, et, al. (2005) J. Virol ; 79: 14562 - 14569. Christy M. Hebner, et, al. (2006) J. Gen. Virol ; 87: 3183 - 3193. Rika van Huizen, et, al. (2003) J. Biol. Chem ; 278: 15558 - 15564.

PKR, PRKR, EIF2AK1, CBL2, RNF55, ADRB2, E2AK2, EIF2AK2, EIF2aK

IHC, IF

208431827

Liquid