PKR (EIF2AK2) (NM 001135651) Humaan Recombinant eiwit

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Purified recombinant protein of Human eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), transcript variant 2, Glu51-Asn191, with N-terminal His-ABP tag, expressed in E. coli, 50ug

EIF2AK1; LEUDEN; PKR; PPP1R83; PRKR

5610

P19525, Q8IW76

NM_001135651

2p22.2

E. coli

N-His-ABP

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

Druggable Genome, Protein Kinase, Transcription Factors

30.3 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

EIF2AK2

Human

NP_001129123

https://www.ncbi.nlm.nih.gov/gene/5610

https://www.uniprot.org/uniprot/P19525

https://www.ncbi.nlm.nih.gov/nuccore/NM_001135651

https://www.ncbi.nlm.nih.gov/nuccore/NP_001129123