PLA1A Antilichaam

PLA1A Antibody: PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.

51365

Q53H76

NP_056984

Human, Rat

Unconjugated

Primary Antibodies

Immunology

PLA1A Antibody is affinity chromatography purified via peptide column.

Cat. No. 1305 - Human Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (75%), Bovine: (71%)

PLA1A Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PLA1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

50 kDa

IgG

At least three isoforms of PLA1A are known to exist; this antibody will detect all three isoforms.

PLA1A

Cat. No. 10-401 - Human Kidney Tissue Slide

Phospholipase A1 member A

Homo sapiens

Sato T, Aoki J, Nagai Y, et al. Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family. J. Biol. Chem. 1997; 272:2192-8.

Aoki J, Nagai Y, Hosono H, et al. Structure and function of phosphatidylserine-specific phospholipase A1. Biochim. Biophys. Acta 2002; 1582:26-32.

Hosono H, Homma M, Ogasawa Y, et al. Expression of phosphatidylserine-specific phospholipase A (1) mRNA in human THP-1-derived macrophages. Cell Transplant. 2010; 19:759-64.

PLA1A Antibody: PSPLA1, PS-PLA1, NMD, PSPLA1, Phospholipase A1 member A, Phosphatidylserine-specific phospholipase A1

ELISA, WB, IF

7706661

Liquid