PLAGL2 Antilichaam

PLAGL2 Antibody: The PLAG (Pleiomorphic adenoma gene) family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2) . PLAG1 is the target gene for the pleiomorphic adenomas of the salivary gland. ZAC1 (PLAGL1) concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a transcriptional cofactor for nuclear receptors. PLAGL2 belongs to the krueppel C2H2-type zinc-finger protein family and contains 6 C2H2-type zinc fingers. It functions as a positive regulator of transcription and localizes to the nucleus. PLAGL2 is ubiquitously expressed with particular abundance in spleen, lung and testis, where it may be involved in cell cycle arrest and apoptosis of tumor cells.

5326

Q9UPG8

NP_002648

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

PLAGL2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

PLAGL2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PLAGL2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

55 kDa

IgG

At least two isoforms are known to exist.

PLAGL2

Pleiomorphic adenoma gene-like 2

Homo sapiens

Kas K, Voz ML, Hensen K, et al. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J. Biol. Chem. 1998; 273:23026-32.

Voz ML, Agten NS, Van de Ven WJ, et al. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Cancer Res. 2000; 60:106-13.

Shu G, Tang Y, Zhou Y, et al. Zac1 is a histone acetylation-regulated NF-kappaB suppressor that mediates histone deacetylase inhibitor-induced apoptosis. Cell Death Differ. 2011; 18:1825-35.

Mizutani A, Furukawa T, Adachi Y, et al. A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis. J. Biol. Chem. 2002; 277:15851-8.

PLAGL2 Antibody: ZNF900, KIAA0198, Zinc finger protein PLAGL2, Pleiomorphic adenoma-like protein 2

ELISA, WB, IHC-P, IF

4505859

Liquid