PLEKHM3 Antilichaam

PLEKHM3 Antibody: PLEKHM3, also known as DAPR, is a member of the M family of Pleckstrin homology domain-containing proteins. PLEKHM3 was initially identified through chromatin immunoprecipitation and CpG microarray analysis examining proteins regulated by myocyte-enhancing factor 2. In C2C12 myoblast cells, PLEKHM3 binds to the PI3K signaling member protein kinase B in the cytosol prior to differentiation into myotubes. Following the initiation of differentiation, PLEKHM3 was also found in membrane fractions. Knockdown of PLEKHM3 expression by RNAi resulted in the inhibition of myotube formation, suggesting that PLEKHM3 is a key component required by myoblasts for orchestrating their differentiation during myogenesis.

389072

Q6ZWE6

Q6ZWE6

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

PLEKHM3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate

1 mg/mL

PLEKHM3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

PLEKHM3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

PLEKHM3

Cat. No. 10-301 - Human Brain Tissue Slide

Pleckstrin homology domain containing, family M, member 3

Homo sapiens

Virtanen C, Paris J, and Takahashi M. Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. J. Biol. Chem.2009; 284:1636-43.

PLEKHM3 Antibody: DAPR, PLEKHM1L, Pleckstrin homology domain-containing family M member 3, PH domain-containing family M member 3

ELISA, WB, IHC-P, IF

172046173

Liquid